:root{--bg-primary: #0b0f19;--bg-secondary: #121826;--bg-card: rgba(21, 28, 44, .75);--border-color: rgba(255, 255, 255, .08);--border-hover: rgba(255, 255, 255, .16);--text-primary: #f3f4f6;--text-secondary: #9ca3af;--text-muted: #6b7280;--primary: #3b82f6;--primary-hover: #2563eb;--primary-light: rgba(59, 130, 246, .15);--accent: #10b981;--accent-light: rgba(16, 185, 129, .15);--warning: #f59e0b;--danger: #ef4444;--danger-light: rgba(239, 68, 68, .12);--shadow-sm: 0 2px 8px rgba(0, 0, 0, .15);--shadow-md: 0 8px 24px rgba(0, 0, 0, .25);--shadow-lg: 0 16px 40px rgba(0, 0, 0, .4);--glass-blur: 16px;--transition: all .3s cubic-bezier(.4, 0, .2, 1);--radius-sm: 8px;--radius-md: 12px;--radius-lg: 16px}[data-theme=light]{--bg-primary: #f0f4f9;--bg-secondary: #ffffff;--bg-card: rgba(255, 255, 255, .85);--border-color: rgba(0, 0, 0, .08);--border-hover: rgba(0, 0, 0, .15);--text-primary: #1f2937;--text-secondary: #4b5563;--text-muted: #9ca3af;--primary: #2563eb;--primary-hover: #1d4ed8;--primary-light: rgba(37, 99, 235, .1);--accent: #059669;--accent-light: rgba(5, 150, 105, .1);--shadow-sm: 0 2px 6px rgba(0, 0, 0, .05);--shadow-md: 0 8px 18px rgba(0, 0, 0, .08);--shadow-lg: 0 12px 30px rgba(0, 0, 0, .12)}*{box-sizing:border-box;margin:0;padding:0}button,input,select,textarea{color:inherit;font-family:inherit;border:none;background:none}body{font-family:Inter,sans-serif;background-color:var(--bg-primary);color:var(--text-primary);min-height:100vh;position:relative;overflow-x:hidden;transition:background-color .4s ease,color .4s ease;line-height:1.5;padding-bottom:40px}.glow-bg{position:absolute;width:350px;height:350px;border-radius:50%;filter:blur(120px);z-index:-1;opacity:.15;pointer-events:none;transition:opacity .5s ease}.glow-1{background:var(--primary);top:-80px;right:-40px}.glow-2{background:var(--accent);bottom:-80px;left:-40px}[data-theme=light] .glow-bg{opacity:.06}.app-container-mobile{width:100%;max-width:740px;margin:0 auto;padding:16px;display:flex;flex-direction:column;gap:16px}.app-header-simple{display:flex;justify-content:space-between;align-items:center;padding:14px 20px;background:var(--bg-card);backdrop-filter:blur(var(--glass-blur));-webkit-backdrop-filter:blur(var(--glass-blur));border:1px solid var(--border-color);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm)}.header-logo{display:flex;align-items:center;gap:12px}.logo-icon{width:38px;height:38px;background:linear-gradient(135deg,var(--primary),var(--accent));border-radius:10px;display:flex;align-items:center;justify-content:center;color:#fff;font-size:1.15rem;box-shadow:0 4px 10px #3b82f633}.logo-text h1{font-family:Outfit,sans-serif;font-size:1.35rem;font-weight:800;letter-spacing:-.4px;line-height:1.1}.logo-text h1 span{color:var(--primary)}.logo-text p{font-size:.75rem;color:var(--text-secondary)}.header-actions{display:flex;align-items:center;gap:12px}.online-badge{display:inline-flex;align-items:center;gap:6px;background:#10b9811f;color:var(--accent);padding:4px 10px;border-radius:20px;font-size:.72rem;font-weight:700;text-transform:uppercase;letter-spacing:.3px;border:1px solid rgba(16,185,129,.2)}.online-badge .dot{width:6px;height:6px;background-color:var(--accent);border-radius:50%;display:inline-block;animation:pulse-dot 2s infinite}@keyframes pulse-dot{0%{transform:scale(.9);opacity:.6}50%{transform:scale(1.2);opacity:1}to{transform:scale(.9);opacity:.6}}.btn-icon{width:36px;height:36px;border-radius:8px;border:1px solid var(--border-color);background:transparent;color:var(--text-primary);display:flex;align-items:center;justify-content:center;cursor:pointer;transition:var(--transition)}.btn-icon:hover{background:var(--border-color);transform:translateY(-1px)}.card{background:var(--bg-card);backdrop-filter:blur(var(--glass-blur));-webkit-backdrop-filter:blur(var(--glass-blur));border:1px solid var(--border-color);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm);overflow:hidden;transition:var(--transition)}.card-header{padding:14px 18px;border-bottom:1px solid var(--border-color);display:flex;align-items:center;gap:10px}.card-header i{color:var(--primary);font-size:1.1rem}.card-header h2{font-family:Outfit,sans-serif;font-size:1.05rem;font-weight:600}.card-body{padding:16px}.card-body.padding-small{padding:12px}.weight-card-modern .weight-card-header{display:flex;justify-content:space-between;align-items:center;padding:14px 18px 6px}.weight-label{font-family:Inter,sans-serif;font-size:.85rem;font-weight:600;color:var(--text-secondary);display:flex;align-items:center;gap:8px}.weight-label i{color:var(--primary)}.weight-display{font-family:Outfit,sans-serif;font-size:1.7rem;font-weight:700;color:var(--text-primary)}.weight-unit{font-size:.95rem;font-weight:500;color:var(--text-secondary);margin-left:2px}.slider-wrapper{display:flex;align-items:center;gap:14px;margin:8px 0 16px}.btn-stepper{width:40px;height:40px;border-radius:50%;border:1px solid var(--border-color);background:#ffffff08;color:var(--text-primary);display:flex;align-items:center;justify-content:center;cursor:pointer;font-size:.95rem;transition:var(--transition)}.btn-stepper:hover{background:var(--border-color);border-color:var(--border-hover)}.modern-slider{flex-grow:1;-webkit-appearance:none;-moz-appearance:none;appearance:none;height:6px;border-radius:3px;background:var(--border-color);outline:none}.modern-slider::-webkit-slider-runnable-track{width:100%;height:6px;cursor:pointer;background:var(--border-color);border-radius:3px}.modern-slider::-webkit-slider-thumb{height:20px;width:20px;border-radius:50%;background:var(--primary);cursor:pointer;-webkit-appearance:none;margin-top:-7px;box-shadow:0 0 10px #3b82f680;transition:var(--transition)}.modern-slider::-webkit-slider-thumb:hover{transform:scale(1.15);background:var(--primary-hover)}.weight-presets{display:flex;justify-content:space-between;gap:8px;overflow-x:auto;padding-bottom:2px}.btn-preset{flex-grow:1;padding:8px 12px;border-radius:8px;border:1px solid var(--border-color);background:#00000026;font-size:.8rem;font-weight:600;cursor:pointer;color:var(--text-secondary);transition:var(--transition);text-align:center;white-space:nowrap}[data-theme=light] .btn-preset{background:#f3f4f6}.btn-preset:hover{border-color:var(--border-hover);color:var(--text-primary)}.btn-preset.active{background:var(--primary-light);border-color:var(--primary);color:var(--primary)}.drugs-grid-container{display:flex;flex-direction:column;gap:12px}.drug-group-header{font-family:Outfit,sans-serif;font-size:.72rem;font-weight:700;color:var(--primary);text-transform:uppercase;letter-spacing:.8px;margin:10px 0 2px 4px;padding-bottom:4px;border-bottom:1px solid var(--border-color)}.drug-group-header:first-of-type{margin-top:2px}.drug-group-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:8px}@media (max-width: 600px){.drug-group-grid{grid-template-columns:repeat(2,1fr)}}.drug-item-card{display:flex;flex-direction:column;justify-content:space-between;padding:12px 14px;border-radius:var(--radius-md);border:1px solid var(--border-color);background:#ffffff05;cursor:pointer;transition:var(--transition);text-align:left;min-height:74px}[data-theme=light] .drug-item-card{background:#f9fafb}.drug-item-card:hover{background:#ffffff0d;border-color:var(--border-hover);transform:translateY(-2px)}.drug-item-card.active{background:var(--primary-light);border-color:var(--primary);box-shadow:0 0 12px var(--primary-light)}.drug-card-name{font-family:Outfit,sans-serif;font-size:.92rem;font-weight:600;color:var(--text-primary);line-height:1.2}.drug-card-meta{display:flex;justify-content:space-between;align-items:center;margin-top:6px;width:100%}.drug-card-unit{font-size:.72rem;color:var(--text-secondary);font-weight:500}.drug-card-badge{font-size:.65rem;font-weight:600;text-transform:uppercase;padding:1px 5px;border-radius:4px}.badge-vasopressor{background:#ef44441f;color:#f87171}.badge-inotropico{background:#f59e0b1f;color:#fbbf24}.badge-vasodilatador{background:#3b82f61f;color:#60a5fa}.badge-sensibilizador{background:#10b9811f;color:#34d399}.active-drug-header{display:flex;flex-direction:column;align-items:flex-start;gap:4px}.drug-title-container{display:flex;align-items:center;gap:10px}.active-drug-header h2{font-family:Outfit,sans-serif;font-size:1.4rem;font-weight:700;letter-spacing:-.3px}.active-drug-header .badge{font-size:.7rem;padding:3px 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16px;border-radius:10px;font-family:Inter,sans-serif;font-size:.85rem;font-weight:600;cursor:pointer;transition:var(--transition)}.btn-primary{background:var(--primary);color:#fff}.btn-primary:hover{background:var(--primary-hover)}.btn-secondary{background:var(--primary-light);color:var(--primary);border:1px solid rgba(59,130,246,.15)}.btn-secondary:hover{background:#3b82f640}.btn-danger-custom{background:var(--danger-light);color:var(--danger);border:1px solid rgba(239,68,68,.15)}.btn-danger-custom:hover{background:#ef444440}.dilution-detail-box{background:#00000026;border:1px solid var(--border-color);border-radius:10px;padding:12px 14px;display:flex;flex-direction:column;gap:8px}[data-theme=light] .dilution-detail-box{background:#f9fafb}.detail-row{display:flex;justify-content:space-between;font-size:.82rem}.detail-label{color:var(--text-secondary)}.detail-value{font-weight:500}.detail-row.highlight{border-top:1px solid var(--border-color);padding-top:8px;font-size:.9rem;font-weight:700}.detail-row.highlight .detail-label{color:var(--text-primary)}.detail-row.highlight .detail-value{color:var(--accent)}.alert-box{display:flex;gap:12px;padding:14px;border-radius:10px;margin-top:16px;border:1px solid rgba(239,68,68,.25);background:var(--danger-light);animation:pulse-danger-subtle 2s infinite alternate}.alert-icon i{font-size:1.25rem;color:var(--danger)}.alert-content h4{font-size:.9rem;font-weight:700;margin-bottom:2px;color:var(--danger)}.alert-content p{font-size:.8rem;line-height:1.35;color:var(--text-secondary)}@keyframes pulse-danger-subtle{0%{box-shadow:0 0 #ef444426}to{box-shadow:0 0 10px 1px #ef44444d}}.inputs-stack{display:flex;flex-direction:column;gap:12px;margin-top:8px}.calc-input-box-modern{background:#0000002e;border:1px solid var(--border-color);border-radius:var(--radius-md);padding:14px;display:flex;flex-direction:column;gap:8px;transition:var(--transition)}[data-theme=light] 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i{color:var(--primary)}.absolute-dose-info strong{color:var(--text-primary)}.accordion-section{display:flex;flex-direction:column;gap:12px;margin-top:4px}.collapsible-card{border:1px solid var(--border-color);background:var(--bg-card);transition:var(--transition)}.collapsible-header{width:100%;padding:14px 18px;display:flex;justify-content:space-between;align-items:center;cursor:pointer;text-align:left;font-family:Outfit,sans-serif;font-size:.95rem;font-weight:600;color:var(--text-primary)}.collapsible-header .header-left{display:flex;align-items:center;gap:8px}.collapsible-header .header-left i{color:var(--primary)}.collapsible-header .arrow-icon{font-size:.8rem;color:var(--text-secondary);transition:transform .3s ease}.collapsible-card.collapsed .collapsible-body{max-height:0;opacity:0;overflow:hidden;padding:0 18px}.collapsible-card:not(.collapsed) .collapsible-body{max-height:1000px;opacity:1;padding:4px 18px 18px;border-top:1px solid var(--border-color);transition:max-height .5s cubic-bezier(0,1,0,1),opacity .3s ease}.collapsible-card:not(.collapsed) .arrow-icon{transform:rotate(180deg)}.receptor-meters{display:flex;flex-direction:column;gap:12px;padding-top:10px}.receptor-bar-group{display:flex;flex-direction:column;gap:6px}.receptor-bar-label{display:flex;justify-content:space-between;font-size:.78rem;font-weight:600}.receptor-bar-label .receptor-name{color:var(--text-primary)}.receptor-bar-label .receptor-effect{color:var(--text-secondary);font-size:.72rem}.receptor-progress-bg{width:100%;height:6px;background:var(--border-color);border-radius:3px;overflow:hidden}.receptor-progress-fill{height:100%;border-radius:3px;transition:width .6s 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var(--border-color);border-radius:var(--radius-lg);box-shadow:var(--shadow-lg);overflow:hidden;z-index:1001;animation:modal-enter .3s cubic-bezier(.34,1.56,.64,1)}@keyframes modal-enter{0%{transform:scale(.9) translateY(15px);opacity:0}to{transform:scale(1) translateY(0);opacity:1}}.modal-header{padding:16px 20px;border-bottom:1px solid var(--border-color);display:flex;justify-content:space-between;align-items:center}.modal-header h2{font-family:Outfit,sans-serif;font-size:1.15rem;font-weight:600;display:flex;align-items:center;gap:8px}.modal-header h2 i{color:var(--primary)}.btn-icon-close{background:transparent;border:none;color:var(--text-secondary);font-size:1.1rem;cursor:pointer;transition:var(--transition);width:28px;height:28px;border-radius:50%;display:flex;align-items:center;justify-content:center}.btn-icon-close:hover{background:var(--border-color);color:var(--text-primary)}.modal-body{padding:20px;display:flex;flex-direction:column;gap:14px}.modal-drug-banner{background:var(--primary-light);color:var(--text-primary);padding:8px 12px;border-radius:8px;font-size:.8rem;border-left:3px solid var(--primary)}.form-group{display:flex;flex-direction:column;gap:4px}.form-group label{font-size:.78rem;font-weight:600;color:var(--text-secondary)}.form-group input[type=text],.form-group input[type=number]{padding:10px;border-radius:8px;border:1px solid var(--border-color);background:var(--bg-primary);color:var(--text-primary);font-family:Inter,sans-serif;font-size:.9rem;transition:var(--transition);width:100%}.form-group input:focus{outline:none;border-color:var(--primary)}.form-row{display:grid;grid-template-columns:1fr 1fr;gap:12px}@media (max-width: 480px){.form-row{grid-template-columns:1fr;gap:10px}}.input-with-unit-small{position:relative;display:flex;align-items:center}.input-with-unit-small input{padding-right:36px!important}.input-with-unit-small .unit-small{position:absolute;right:10px;font-size:.75rem;font-weight:600;color:var(--text-muted);pointer-events:none}.live-preview-box{background:#00000026;border:1px solid var(--border-color);border-radius:8px;padding:10px 14px;display:flex;justify-content:space-between;font-size:.78rem;color:var(--text-secondary)}[data-theme=light] .live-preview-box{background:#f9fafb}.live-preview-box strong{color:var(--accent)}.modal-footer{display:flex;justify-content:flex-end;gap:10px;margin-top:6px}.app-footer{text-align:center;padding:12px 0;font-size:.7rem;color:var(--text-muted);border-top:1px solid var(--border-color)}.hidden{display:none!important}